Recent Research shows Endurance Exercise training Beneficially Modifies Gut Microbiota composition.
Six weeks of training: 1) Reduced Inflammation-Causing Microbes (Proteobacteria), and 2) Increased Microbes Linked to Improved Metabolism (Akkermansia).
Apart from these, exercise had other beneficial health effects, says Academy of Finland research fellow Satu Pekkala from the Faculty of Sport and Health Sciences of the University of Jyväskylä.
CHOLESTEROL & BLOOD VESSELS
"We found that phospholipids and cholesterol in VLDL particles decreased in response to exercise. These changes are beneficial for cardiometabolic health."
Exercise training also decreased Vascular adhesion protein-1 activity, which can have beneficial anti-inflammatory effects especially on Blood Vessels.
- THE STUDY - Benefits to Gut Microbiota
The exercise program for overweight women was completed by 17 subjects. Over a six-week period, previously sedentary women participated in three training sessions per week with a static bicycle.
The training intensity was controlled with heart rate.
During the study, other lifestyle factors, including diet, were not changed so that that the effects of the exercise could be observed more accurately.
Eveliina Munukka, Juha P. Ahtiainen, Pere Puigbó, Sirpa Jalkanen, Katja Pahkala, Anniina Keskitalo, Urho M. Kujala, Sami Pietilä, Maija Hollmén, Laura Elo, Pentti Huovinen, Giuseppe D'Auria, Satu Pekkala. Six-Week Endurance Exercise Alters Gut Metagenome That Is not Reflected in Systemic Metabolism in Over-weight Women. Frontiers in Microbiology, 2018; 9 DOI: 10.3389/fmicb.2018.02323, and www.sciencedaily.com/releases/2018/10/181015105451.htm... See moreSee less
Natural Product Found to Reduce the Level of Damaged Cells in the Body, Caused by Aging
Previous research published earlier this year in Nature Medicine involving University of Minnesota Medical School faculty Paul D. Robbins and Mayo Clinic investigators, showed it was possible to reduce the burden of damaged cells, termed senescent cells, and extend lifespan and improve health, even when treatment was initiated late in life.
They now have shown that treatment of aged mice with the natural product Fisetin, found in many fruits and vegetables, also has significant positive effects on health and lifespan.
As people age, they accumulate damaged cells. When the cells get to a certain level of damage they go through an aging process of their own, called cellular senescence.
The cells also release inflammatory factors that tell the immune system to clear those damaged cells. A younger person's immune system is healthy and is able to clear the damaged cells.
But as people age, they aren't cleared as effectively. Thus they begin to accumulate, cause low level inflammation and release enzymes that can degrade the tissue.
Robbins and fellow researchers found a natural product, called Fisetin, reduces the level of these damaged cells in the body.
They found this by treating mice towards the end of life with this compound and see improvement in health and lifespan. The paper, "Fisetin is a senotherapeutic that extends health and lifespan," was recently published in EBioMedicine.
"These results suggest that we can extend the period of health, termed healthspan, even towards the end of life," said Robbins.
Matthew J. Yousefzadeh, Yi Zhu, Sara J. McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I. Melos, Tamar Pirtskhalava, Christina L. Inman, Collin McGuckian, Erin A. Wade, Jonathon I. Kato, Diego Grassi, Mark Wentworth, Christin E. Burd, Edgar A. Arriaga, Warren L. Ladiges, Tamara Tchkonia, James L. Kirkland, Paul D. Robbins, Laura J. Niedernhofer. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine, 2018; DOI: 10.1016/j.ebiom.2018.09.015, and www.sciencedaily.com/releases/2018/10/181002114024.htm... See moreSee less